Neurons orchestrating synapse-driven synchrony in the developing hippocampus
نویسندگان
چکیده
منابع مشابه
Plasticity of the Developing Glutamate Synapse in the Hippocampus
Synapses are highly plastic, i.e. they have the ability to change their signaling strength both in the shortand long-term (e.g. long-term potentiation LTP) in response to specific patterns of activity. In the developing brain synaptic plasticity promotes activity-dependent development, whereas in the mature brain synaptic plasticity forms the basis for learning and memory. Although both develop...
متن کاملCadherin-9 Regulates Synapse-Specific Differentiation in the Developing Hippocampus
Our understanding of mechanisms that regulate the differentiation of specific classes of synapses is limited. Here, we investigate the formation of synapses between hippocampal dentate gyrus (DG) neurons and their target CA3 neurons and find that DG neurons preferentially form synapses with CA3 rather than DG or CA1 neurons in culture, suggesting that specific interactions between DG and CA3 ne...
متن کاملGABAergic hub neurons orchestrate synchrony in developing hippocampal networks.
Brain function operates through the coordinated activation of neuronal assemblies. Graph theory predicts that scale-free topologies, which include "hubs" (superconnected nodes), are an effective design to orchestrate synchronization. Whether hubs are present in neuronal assemblies and coordinate network activity remains unknown. Using network dynamics imaging, online reconstruction of functiona...
متن کاملCircadian synchrony in networks of protein rhythm driven neurons
The interaction between gene activation and cellular activity has recently emerged as a critical aspect of brain behavior, but the dynamics of networks incorporating these interactions are poorly understood. An interesting phenomena arises when the genetic activation oscillates endogenously and a network of such cells synchronize to a coherent rhythm, such as is the case with the suprachiasmati...
متن کاملHomeostatic synapse-driven membrane plasticity in nucleus accumbens neurons.
Stable brain function relies on homeostatic maintenance of the functional output of individual neurons. In general, neurons function by converting synaptic input to output as action potential firing. To determine homeostatic mechanisms that balance this input-output/synapse-membrane interaction, we focused on nucleus accumbens (NAc) neurons and demonstrated a novel form of synapse-to-membrane h...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Frontiers in Neuroscience
سال: 2009
ISSN: 1662-453X
DOI: 10.3389/conf.neuro.01.2009.16.044